Biologically structured materials


  • Relly Victoria V. Petrescu Bucharest Polytechnic University, Romania
  • Raffaella Aversa Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy
  • Antonio Apicella Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy
  • Florian Ion Tiberiu Petrescu IFToMM



Biologically Structured Materials, Techno-structured materials Hybrid materials, Biotechnology, Bioengineering, Biomaterials, Bioactive scaffolds, Biomimetics, Endochondral ossification patterns, Finite Element Analysis, Osteointegration, Osteoinduction,


In this paper bio-tissue mathematical modeling serves as a central repository to interface design, simulation, and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesized for the use of the new biologically techno-structured hybrid materials.

Author Biographies

Relly Victoria V. Petrescu, Bucharest Polytechnic University, Romania

Bucharest Polytechnic University, Romania

Raffaella Aversa, Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy

Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy

Antonio Apicella, Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy

Advanced Materials Lab, Department of Architecture and Industrial Design, Second University of Naples, Aversa, Italy

Florian Ion Tiberiu Petrescu, IFToMM

Ph.D. Eng. Florian Ion T. PETRESCU

Senior Lecturer at UPB (Bucharest Polytechnic University), Theory of Mechanisms and Robots department,

Date of birth: March.28.1958; Higher education: Polytechnic University of Bucharest, Faculty of Transport, Road Vehicles Department, graduated in 1982, with overall average 9.63;

Doctoral Thesis: "Theoretical and Applied Contributions About the Dynamic of Planar Mechanisms with Superior Joints".

Expert in: Industrial Design, Mechanical Design, Engines Design, Mechanical Transmissions, Dynamics, Vibrations, Mechanisms, Machines, Robots.


Member ARoTMM, IFToMM, SIAR, FISITA, SRR, AGIR. Member of Board of SRRB (Romanian Society of Robotics).


ANNUNZIATA, M.; AVERSA, R.; APICELLA, A.; ANNUNZIATA, A.; APICELLA, D.; BUONAIUTO, C.; GUIDA, L. (2006) In vitro biological response to a light-cured composite when used for cementation of composite inlays, Dental Materials, v. 22, n. 12, p. 1081-1085. Doi: 10.1016/J.DENTAL.2005.08.009

ANNUNZIATA, M.; GUIDA, L.; PERILLO, L.; AVERSA, R.; PASSARO, I. (2008) Biological response of human bone marrow stromal cells to sandblasted titanium nitride-coated implant surfaces. J. Mater. Sci. Mater. Med., v. 19, p. 3585-3591. Doi: 10.1007/s10856-008-3514-2.

APICELLA, A.; CAPPELLO, B.; DEL NOBILE, M. A.; LA ROTONDA, M. I.; MENSITIERI, G. (1993) Poly(ethylene oxide) (PEO) and different molecular weight PEO’s blends monolithic devices for drug release. Biomaterials, v. 142, p. 83-90. Doi: 10.1016/0142-9612(93)90215-N

APICELLA, A.;HOPFENBERG, H. (1982) Water-swelling behavior of an ethylene-vinyl alcohol copolymer in the presence of sorbed sodium chloride. J. Applied Polymer Sci., v. 27, p. 1139-1148. Doi: 10.1002/app.1982.070270404

APICELLA, D.; AVERSA, R.; FERRO, E.; IANNIELLO, D.; APICELLA, A. (2010) The importance of cortical bone orthotropicity, maximum stiffness direction and thickness on the reliability of mandible numerical models, Journal of Biomedical Materials Research - Part B Applied Biomaterials, v. 93, n. 1, April, p. 150-163, n. 8: Doi: 10.1002/jbm.b.31569

APICELLA, D.; VELTRI, M.; BALLERI, P.; APICELLA, A.; FERRARI, M. (2011) Influence of abutment material on the fracture strength and failure modes of abutment-fixture assemblies when loaded in a bio-faithful simulation, Clinical Oral Implants Research, v. 22, n. 2, February, p. 182-188: Doi: 10.1111/j.1600-0501.2010.01979.x

APICELLA, D.; AVERSA, R.; TATULLO, M.; SIMEONE, M.; SAYED, S.; MARRELLI, M.; APICELLA, A.; (2015) Direct restoration modalities of fractured central maxillary incisors: A multi-levels validated finite elements analysis with in vivo strain measurements, Dental Materials, v. 31, n. 12, p. e289-e305, Doi: 10.1016/

AVERSA, R.; APICELLA, D.; PERILLO, L.; SORRENTINO, R.; ZARONE, F.; FERRARI, F.; APICELLA, A. (2009) Non-linear elastic three-dimensional finite element analysis on the effect of endocrown material rigidity on alveolar bone remodeling process. Dental materials, v. 25, p. 678–690: Doi: 10.1016/

AVERSA, R.; PETRESCU, F. I. T.; PETRESCU, R. V.; APICELLA, A. (2016a) Biomimetic FEA bone modeling for customized hybrid biological prostheses development. Am. J. Applied Sci., v.13, p. 1060-1067. Doi: 10.3844/ajassp.2016.1060.1067

AVERSA, R.; PARCESEPE, D.; PETRESCU, R. V.; CHEN, G.; PETRESCU, F. I. T.; TAMBURRINO, F.; APICELLA, A. (2016b) Glassy Amorphous Metal Injection Molded Induced Morphological Defects, Am. J. Applied Sci., v. 13, n. 12, p. 1476-1482.

AVERSA, R.; PETRESCU, R. V.; PETRESCU, F. I. T.; APICELLA, A. (2016c) Smart-Factory: Optimization and Process Control of Composite Centrifuged Pipes, Am. J. Applied Sci., v. 13, n. 11, p. 1330-1341.

AVERSA, R.; TAMBURRINO, F.; PETRESCU, R. V.; PETRESCU, F. I. T.; ARTUR, M.; CHEN, G.; APICELLA, A. (2016d) Biomechanically Inspired Shape Memory Effect Machines Driven by Muscle like Acting NiTi Alloys, Am. J. Applied Sci., v.13, n. 11, p. 1264-1271.

AVERSA, R.; PETRESCU, R. V.; APICELLA, A.; PETRESCU, F. I. T. (2017a) Nano- Diamond Hybrid Materials for Structural Biomedical Application. American Journal of Biochemistry and Biotechnology, v.13, n. 1, p. 34-41. Doi: 10.3844/ajbbsp.2017.34.41

AVERSA, R.; PETRESCU, R. V.; APICELLA, A.; PETRESCU, F. I. T. (2017b) Modern Transportation and Photovoltaic Energy for Urban Ecotourism. TRANSYLVANIAN REVIEW OF ADMINISTRATIVE SCIENCES Special Issue, p. 5-20. Doi: 10.24193/tras.SI2017.1

AVERSA, R.; PETRESCU, R. V.; APICELLA, A.; PETRESCU, F. I. T. (2019) A Nanodiamond for Structural Biomimetic Scaffolds. Engineering Review, v. 39, n. 1, p. 81-89. Doi:

BADZIAG, P.; VERWOERD, W. S.; ELLIS, W. P.; GREINER, N. R. (1990) Nanometre-sized diamonds are more stable than graphite. Nature, v. 343, p. 244-245. Doi: 10.1038/343244a0

BARNARD, A. S.; RUSSO, S. P.; SNOOK, I. K. (2003) Structural relaxation and relative stability of nanodiamond morphologies. Diamond Relat. Mater., v. 12, p. 1867-1872. Doi: 10.1016/S0925-9635(03)00275-9

BARNARD, A. S.; STERNBERG, M. (2007) Crystallinity and surface electrostatics of diamond nanocrystals. J. Mater. Chem., v. 17, p. 4811-4819. Doi: 10.1039/b710189a

BEAUPRE G. S.; HAYES W. C. (1985) Finite Element Analysis of a three dimensional open-celled model for trabecular bone. J. Biomech. Eng., v. 107, p. 249-56, PMID: 4046566

BONFIELD, W.; GRYNPAS, M. D.; TULLY, A. E.; BOWMAN, J.; ABRAM, J. (1981) Hydroxyapatite reinforced polyethylene — a mechanically compatible implant material for bone replacement. Biomaterials, v. 2, p. 185-186. Doi: 10.1016/0142- 9612(81)90050-8

COMERUN, H. U. (1986) Six-year results with a microporous-coated metal hip prosthesis, Clin. Orthop. 208 81

ČEPELAK I.; DODIG, S.; ČULIĆ, O. (2013) Magnesium-more than a common cation. Med. Sci., v. 39, p. 47-68.

CHANG, Y. R.; HSU, J. H.; K. CHEN, K.; FANN, W. (2008) Mass production and dynamic imaging of fluorescent nanodiamonds. Nature Nanotech., v. 3, p. 284-288. Doi: 10.1038/nnano.2008.99

CHEN, Q.; ZHU, C.; THOUAS, G. A. (2012) Progress and challenges in biomaterials used for bone tissue engineering: Bioactive glasses and elastomeric composites. Progress. Biomater., v. 1, p. 1-22. Doi: 10.1186/2194-0517-1-2

CHOW, E. K.; ZHANG, X. Q.; CHEN, M.; LAM, R.; ROBINSON, E. (2010) Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Sci. Transl. Med., v. 3, p. 73ra21-73ra21. Doi: 10.1126/scitranslmed.3001713

CORMACK, A. N.; TILOCCA, A. (2012) Structure and biological activity of glasses and ceramics. Philos. Trans. Math. Phys. Eng. Sci., v. 370, p. 1271-1280. Doi: 10.1098/rsta.2011.0371

DAVIS, P. A.; HUANG, S. J.; NICOLAIS, L.; AMBROSIO, L. (1991) Modified PHEMA Hydrogels. In: Szycher M, editor. High performance biomaterials. Lancaster, PA, USA: Technonic. p. 343–68.

FILMON, R.; GRIZON, F.; BASLIE, M. F.; CHAPPARD, D. (2002) Effects of negatively charged groups (carboxymethyl) on the calcification of poly(2- hydroxyethylmethacrylate). Biomaterials, v. 23, p. 3053–9.

FROST, H. M. (1964) Mathematical elements of lamellar bone remodeling. Springfield: Charles C Thomas. p. 22–25.

FROST, H. M. (1990) Structural adaptations to mechanical usage (SATMU). 2. Redifining Wolff’s law: the bone remodelling problem. Anat Rec, v. 226, p. 414–22.

FROST, H. M. (2003) update of bone physiology and Wolff’s law for clinicians. Angle Orthod, v. 74, p. 3–15.

FROST, H. M. (1994) Wolff’s law and bone’s structural adaptations to mechanical usage: an overview for clinicians. Angle Orthod, v. 64, p. 175–88.

GRAMANZINI, M.; GARGIULO, S.; ZARONE, F.; MEGNA, R.; APICELLA, A.; AVERSA, R.; SALVATORE, M.; MANCINI, M.; SORRENTINO, R.; BRUNETTI, A. (2016) Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: A pilot study in minipig model. Dental Materials, v. 32, n. 6, p. 794-806: Doi: 10.1016/

GORUSTOVICH, A. A.; ROETHER, J. A.; BOCCACCINI, A. R. (2010) Effect of bioactive glasses on angiogenesis: A review of in vitro and in vivo evidences. Tissue Eng. Part B Rev., v. 16, p. 199-207. Doi: 10.1089/ten.TEB.2009.0416

GREINER, N. R.; PHILLIPS, D. S.; JOHNSON, J. D.; VOLK, F. (1988) Diamonds in detonation soot. Nature, v. 333, p. 440-442. Doi: 10.1038/333440a0

HALPIN J. C.; KARDOS J. L. (1976) Halpin-Tsai equations: A review, Polymer Engineering and Science, v. 16, n. 5, p. 344-352

HEINEMANN, S.; HEINEMANN, C.; WENISCH, S.; ALT, V.; WORCH, H. (2013) Calcium phosphate phases integrated in silica/collagen nanocomposite xerogels enhance the bioactivity and ultimately manipulate the osteoblast/osteoclast ratio in a human co-culture model. Acta Biomaterialia, v. 9, p. 4878-4888. Doi: 10.1016/j.actbio.2012.10.010

HENCH, L. L.; POLAK, J. M. (2002) Third-generation biomedical materials. Science, v. 295, p. 1014-1017. Doi: 10.1126/science.1067404

HENCH, L. L.; THOMPSON, I. (2010) Twenty-first century challenges for biomaterials. J. Royal Society Interface, v. 7, p. S379-S391. Doi: 10.1098/rsif.2010.0151.focus

HENCH, L. L.; WILSON, J. (1993) An introduction to bioceramics. World Sci., v. 1, p. 396-396. Doi: 10.1142/2028

HOLLEY, R. H.; HOPFENBERG, H. B.; V. STANNETT, V. (1970) Anomalous transport of hydrocarbons in polystyrene. Polymer Eng. Sci., v.10, p. 376-382. Doi: 10.1002/pen.760100612

HOPPE, A.; GÜLDAL, N. S.; BOCCACCINI, A. R. (2011) A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials, v. 32, p. 2757-2774. DOI: 10.1016/j.biomaterials.2011.01.004

HUISKES, R.; WEINANS, H.; GROOTENBOER, H. J.; DALSTRA, M.; FUDULA, B.; SLOOFF, T. J. (1987) Adaptive bone remodeling theory applied to prosthetic- design analysis. J Biomech, v. 20, p. 1135–1150.

HUTMACHER, D. W. (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials, v. 21, p. 2529-2543. Doi: 10.1016/S0142-9612(00)00121-6

JARRE, G.; LIANG, Y. J.; BETZ, P.; LANG, D.; KRUEGER, A. (2011) Playing the surface game-Diels-Alder reactions on diamond nanoparticles. Chem. Commun., v. 47, p. 544-546. Doi: 10.1039/C0CC02931A

JONES, J. R.; CLARE, A. G. (2012) Bio-Glasses. An Introduction. 1st Edn., Wiley, Chichester, ISBN-10: 1118346475, p. 320.

JULIEN, M.; MAGNE, D.; MASSON, M.; ROLLI-DERKINDEREN, M.; CHASSANDE, O. (2007) Phosphate stimulates matrix Gla protein expression in chondrocytes through the extracellular signal regulated kinase signaling pathway. Endocrinology, v. 148, p. 530-537. Doi: 10.1210/en.2006-0763

KABRA, B.; GEHRKE, S. H.; HWANG, S. T.; RITSCHEL, W. (1991) Modification of the dynamic swelling behaviour of pHEMA. J. Applied Polym. Sci., v.42, p. 2409- 2416. Doi: 10.1002/app.1991.070420906

KARAGEORGIOU, V.; KAPLAN, D. (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials, v. 26, p. 5474-5491. Doi: 10.1016/j.biomaterials.2005.02.002

KIM, H. W.; KNOWLES, J. C.; KIM, H. E. (2004) Development of hydroxyapatite bone scaffold for controlled drug release via poly(ϵ-caprolactone) and hydroxyapatite hybrid coatings. J. Biomed. Mater. Res. Part B: Applied Biomater., v. 70, n. 240-249. Doi: 10.1002/jbm.b.30038

KRUEGER, A.; STEGK, J.; LIANG, Y. J.; LU, L.; JARRE, G. B. (2008) Nanodiamond: Simple and efficient functionalization of detonation diamond. E Langmuir, v. 24, p. 4200-4204. Doi: 10.1021/la703482v

KRUEGER, A.; LIANG, Y. J.; JARRE, G. B.; STEGK, J. (2006) Surface functionalisation of detonation diamond suitable for biological applications. J. Mater. Chem., v. 16, p. 2322-2328. Doi: 10.1039/B601325B

LAI, L.; BARNARD, A. S. (2011a) Modeling the thermostability of surface functionalisation by oxygen, hydroxyl and water on nanodiamonds. Nanoscale, v. 3, p. 2566-2575. Doi: 10.1039/c1nr10108k

LAI, L.; BARNARD, A. S. (2011b) Stability of nanodiamond surfaces exposed to N, NH and NH2. J. Phys. Chem. C, v. 115, p. 6218-6228. Doi: 10.1021/jp1111026

MANO, J. F.; SOUSA, R. A.; BOESEL, L. F.; NEVES, N. M.; REIS, R. L. (2004) Bioinert, biodegradable and injectable polymeric matrix composites for hard tissue replacement: State of the art and recent developments. Composi. Sci. Technol., v. 64, p. 789-817. Doi: 10.1016/j.compscitech.2003.09.001

MARRELLI, M.; FALISI, G.; APICELLA, A.; APICELLA, D.; AMANTEA, M.(2015) Behaviour of dental pulp stem cells on different types of innovative mesoporous and nanoporous silicon scaffolds with different functionalizations of the surfaces. J. Biol. Regulators Homeostatic Agents, v. 9, p. 991-997. PMID: 26753666

MARTIN, R. B.; BURR, D. B.; SHARKEY, N. A. (1998) Skeletal Tissue Mechanics. 1st Edn., Springer, New York, ISBN-10: 0387984747, p. 392.

MOHAN, N.; CHEN, C. S.; HSIEH, H. H.; WU, Y. C.; CHANG, H. C. (2010) In vivo imaging and toxicity assessments of fluorescent nanodiamonds in Caenorhabditis elegans. Nano Lett., v. 10, p. 3692-3699. Doi: 10.1021/nl1021909

MONTHEARD, J. P.; CHATZOPOULOS, M.; CHAPPARD, D. (1992) 2-hydroxyethylmethacrylate HEMA; chemical properties and applications in biomedical fields. J. Macromol. Sci. Macromol. Rev., v. 32, p. 1-34. Doi: 10.1080/15321799208018377

MORALES-HERNANDEZ, D. G.; GENETOS, D.C.; WORKING, D. M.; MURPHY, K. C.; LEICH, J. K. (2012) Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J. Funct. Biomat., v. 23, p. 382-397. Doi: 10.3390/jfb3020382

MOURIÑO, V.; CATTALINI, J. P.; BOCCACCINI, A. R. (2012) Metallic ions as therapeutic agents in tissue engineering scaffolds: An overview of their biological applications and strategies for new developments. J. Royal Society Interface, v. 9, p. 401-419. Doi: 10.1098/rsif.2011.0611

NICOLAIS, L.; APICELLA, A.; NOTARISTEFANO, C. (1984) Time-temperature superposition of n-hexane sorption in polystyrene. J. Membrane Sci., v. 18, p. 187-196. Doi: 10.1016/S0376-7388(00)85033-4

OZAWA, M.; INAGUMA, M.; TAKAHASHI, M.; KATAOKA, F.; RÜGER, A. (2007) Preparation and behavior of brownish, clear nanodiamond colloids. Adv. Mater., v. 19, p. 1201-1206. Doi: 10.1002/adma.200601452

OSSWALD, S.; YUSHIN, G.; MOCHALIN, V.; KUCHEYEV, S. O.; GOGOTSI, Y. (2006) Control of sp2/sp3 carbon ratio and surface chemistry of nanodiamond powders by selective oxidation in air. J. Am. Chem. Soc., v. 128, p. 11635-11642. DOI: 10.1021/ja063303n

PARFITT, A. M. (1983) The Physiological and Clinical Significance of Bone Histomorphometric Data. In: Bone Histomorphometry: Techniques and Interpretation, Recker, R.R. (Ed.), CRC Press, Boca Raton, p. 143-223.

PARFITT, A. M. (1994) Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. J. Cell Biochem., v. 55, p. 273-286. DOI: 10.1002/jcb.240550303

PELUSO, G.; PETILLO, O.; ANDERSON, J. M.; AMBROSIO, M.; NICOLAIS, L. (1997) The differential effects of poly(2-hydroxyethylmethacrylate) and poly(2- hydroxyethylmethacrylate)/poly(caprolactone) polymers on cell proliferation and collagen synthesis by human lung fibroblasts. J. Biomed. Mater. Res., v. 34, p. 327- 336. Doi: 10.1002/(SICI)1097-4636(19970305)34:3<327::AID-JBM7>3.0.CO;2-M

PERILLO, L.; SORRENTINO, R.; APICELLA, D.; QUARANTA, A.; GHERLONE, E. D. (2010) Nonlinear visco-elastic finite element analysis of porcelain veneers: A submodelling approach to strain and stress distributions in adhesive and resin cement. J. Adhesive Dentistry, v. 12, p. $03-413.

PETRESCU, F. I. T.; CALAUTIT, K. J. (2016a) About Nano Fusion and Dynamic Fusion, Am. J. Applied Sci., v. 13, n. 3, p. 261-266.

PETRESCU, F. I. T.; CALAUTIT, K. J. (2016b) About the Light Dimensions, Am. J. Applied Sci., v. 13, n. 3, p. 321-325.

PETRESCU, F. L.; BUZEA, E.; NĂNUŢ, L.; NEACŞA, M.; NAN, C. (2015) The role of antioxidants in slowing aging of skin in a human, Analele Univers. Craiova Biologie Horticultura Tehn. Prel. Prod. Agr. Ing. Med., v. 20, p. 567-574.

PETRESCU, F. I. T.; APICELLA, A.; AVERSA, R.; PETRESCU, R. V.; CALAUTIT, J. K. (2016a) Something about the Mechanical Moment of Inertia, Am. J. Applied Sci., v. 13, n. 11, p. 1085-1090.

PETRESCU, R. V.; AVERSA, R.; APICELLA, A.; LI, S.; CHEN, G.; PETRESCU, F. I. T. (2016b) Something about Electron Dimension, Am. J. Applied Sci., v. 13, n. 11, p. 1272-1276.

PETRESCU, R. V.; AVERSA, R.; APICELLA, A.; BERTO, F.; LI, S.; PETRESCU, F. I. T. (2016c) Ecosphere Protection through Green Energy, Am. J. Applied Sci., v. 13, n. 10, p. 1027-1032.

PETRESCU, F. I. T.; APICELLA, A.; PETRESCU, R. V.; KOZAITIS, S. P.; BUCINELL, R. B.; AVERSA, R.; ABU-LEBDEH, T. M. (2016d) Environmental Protection through Nuclear Energy, Am. J. Applied Sci., v. 13, n. 9, p. 941-946.

PETRESCU, F. I. T.; PETRESCU, R. V. (2017) The Computer Algorithm for Machine Equations of Classical Distribution. Journal of Materials and Engineering Structures, v. 4, n. 4, p. 193-209.

PETRESCU, F. I. T.; PETRESCU, R. V. (2018) Inverse Kinematics to a Stewart Platform. Journal of Materials and Engineering Structures, v. 5, n. 2, p. 111-122.

PETRESCU, F. I. T.; PETRESCU, R. V. (2019) Nuclear hydrogen structure and dimensions, International Journal of Hydrogen Energy, v. 44, n. 21, p. 10833-10837.

PETRESCU, F. I. T. (2019) About the nuclear particles’ structure and dimensions. Comp. Part. Mech., v. 6, n. 2, p. 191-194.

PRASHANTHA, K.; VASANTH KUMAR PAI K; SHERIGARA, B. S.; PRASANNAKUMAR, S. (2001) Interpenetrating polymer networks based on polyol modified castor oil polyurethane and poly-(2-hydroxyethylmethacrylate): synthesis, chemical, mechanical and thermal properties, bull. Mater Sci., v. 24, n. 5, p. 535–548.

REILLY, D. T.; BURNESTAIN A. H. (1974) The mechanical properties of cortical bone. The J. Of bone and Joint Surgery, v. 56 A, n. 5, p. 1001-1021

REILLY, D. T.; BURNESTAIN A. H. (1975) The elastic and ultimate properties of compact bone tissue. J. Biomechanics, v. 8, p. 393-405, Doi:10.1016/0021- 9290(75)90075-5

SCHIRALDI, C.; D’AGOSTINO, A.; OLIVA, A.; FLAMMA, F.; ROSA, A. (2004) Development of hybridmaterials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation. Biomaterials, v. 25, p. 3645-3653. Doi: 10.1016/j.biomaterials.2003.10.059

SCHRAND, A. M.; JOHNSON, J.; DAI, L.; ŌSAWA, E. (2009a) Cytotoxicity and Genotoxicity of Carbon Nanomaterials. In: Safety of Nanoparticles: From Manufacturing to Medical Applications, Nanostructure Science and Technology. Webster, T.J. (Ed.), ISSN-10: 1571-5744, p. 159-187.

SCHRAND, A. M.; HENS, S. A. C.; SHENDEROVA, O. A. (2009b) Nanodiamond particles: Properties and perspectives for bioapplications. Crit. Rev. Solid State Mater. Sci., v. 34, p. 18-74. Doi: 10.1080/10408430902831987

SCHWARTZ-DABNEY, C. L.; DECHOW, P. C. (2003) Variation in cortical material properties throughout the human dentate mandible. Am. J. Phys. Anthropol., v. 120, p. 252-277. Doi: 10.1002/ajpa.10121

SHENDEROVA, O.; KOSCHEEV, A.; ZARIPOV, N.; PETROV, I.; SKRYABIN, Y. (2011) Surface chemistry and properties of ozone-purified detonation nanodiamonds. J. Phys. Chem. C., v. 115, p. 9827-9837. Doi: 10.1021/jp1102466

SORRENTINO, R.; APICELLA, D.; RICCIO, C.; GHERLONE, E. D.; ZARONE, F. (2009) Nonlinear visco-elastic finite element analysis of different porcelain veneers configuration. J. Biomed. Mater. Res., v. 91, p. 727-736. Doi: 10.1002/jbm.b.31449

SORRENTINO, R.; AVERSA, R.; FERRO, V.; AURIEMMA, T.; ZARONE, F. (2007) Three-dimensional finite element analysis of strain and stress distributions in endodontically treated maxillary central incisors restored with different post, core and crown materials. Dent Mater., v.23, p. 983-993. Doi: 10.1016/

SYED, J.; DHARRAB, A. A. L.; ZAFA, M. S.; KHAND, E.; AVERSA, R.; PETRESCU, R. V. V.; APICELLA, A.; PETRESCU, F. I. T. (2017) Influence of Curing Light Type and Staining Medium on the Discoloring Stability of Dental Restorative Composite. American Journal of Biochemistry and Biotechnology, v. 13, n. 1, p. 42-50. Doi: 10.3844/ajbbsp.2017.42.50

TAYLOR, D.; HAZENBERG, J. G.; LEE, T. C. (2007) Living with cracks: Damage and repair in human bone. Nat. Mater., v. 6, p. 263-268. Doi: 10.1038/nmat1866

TÖYRÄSA, J.; LYYRA-LAITINENA, T.; NIINIMÄKIB, M.; LINDGRENC, R.; NIEMINENB, M. T. (2001) Estimation of the Young's modulus of articular cartilage using an arthroscopic indentation instrument and ultrasonic measurement of tissue thickness. J. Biomechan., v.34, p. 251-256. Doi: 10.1016/S0021- 9290(00)00189-5

VIECELLI, J. A.; BASTEA, S.; GLOSLI, J. N.;REE, F. H. (2001) Phase transformations of nanometer size carbon particles in shocked hydrocarbons and explosives. J. Chem. Phys., v. 115, p. 2730-2736. Doi: 10.1063/1.1386418

WOLFF J. (1892) Das Gesetz der Transformation der Knochen. Berlin: A Hirschwald.

XIAO, J.; OUYANG, G.; LIU, P.; WANG, C. X.; YANG, G. W. (2014) Reversible Nanodiamond-Carbon Onion Phase Transformations, Nano Letters, ACS publications, p. 3645-3652: Doi: 10.1021/nl5014234

YUAN, Y.; WANG, X.; JIA, G.; LIU, J. H.; WANG, T. (2010) Pulmonary toxicity and translocation of nanodiamonds in mice. Diamond Relat. Mater., v. 19, p. 291-299. Doi: 10.1016/j.diamond.2009.11.022

ZHANG, Q.; MOCHALIN, V. N.; NEITZEL, I.; KNOKE, I. Y.; HAN, J. (2011) Fluorescent PLLA-nanodiamond composites for bone tissue engineering. Biomaterials, v. 32, p. 87-94. Doi: 10.1016/j.biomaterials.2010.08.090